While challenges remain in malaria control towards elimination, new guidelines and recently
approved vaccines offer hope. Monitoring for continued vaccine and chemoprevention …

Type I hypersensitivity, or so-called type I allergy, is caused by Th2-mediated immune
responses directed against otherwise harmless environmental antigens. Currently, allergen …

Malaria, caused by Plasmodium parasites, remains one of the most devastating infectious
diseases worldwide, despite control efforts to lower morbidity and mortality. Both advanced …

Historically Plasmodium falciparum has followed a pattern of drug resistance first appearing
in low-transmission settings before spreading to high-transmission settings. Several features …

Attenuated sporozoites provide a valuable model for exploring protective immunity against
the malarial liver stage, guiding the design of highly efficient vaccines to prevent malaria …

Adjuvants are vaccine components that can boost the type, magnitude, breadth, and
durability of an immune response. We have previously demonstrated that certain adjuvant …

Insect vector-borne diseases (VBDs) pose significant global health challenges, particularly
in tropical and subtropical regions. The WHO has launched the “Global Vector Control …

Vaccines are an effective way to prevent the emergence and spread of antibiotic resistance
by preventing diseases and establishing herd immunity. However, the reduced effectiveness …

Abstract Background The RTS, S/AS01E (RTS, S) malaria vaccine is recommended for
children in malaria endemic areas. This phase 2b trial evaluates RTS, S fractional-and full …

Abstract The RTS, S/AS02A malaria vaccine is based on the Plasmodium falciparum
circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We …