The neuropharmacological community has shown a strong interest in AMPA receptors as
critical components of excitatory synaptic transmission during the last fifteen years. AMPA …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the first
and second motoneurons (MNs), associated with muscle weakness, paralysis and finally …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor
neurons, causing progressive muscle weakness and respiratory failure. The presence of an …

Traumatic brain injury (TBI) strongly correlates with neurodegenerative disease. However, it
remains unclear which neurodegenerative mechanisms are intrinsic to the brain and which …

Hexanucleotide repeat expansions in the C9orf72 gene are the most common cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Due to the lack of trunk …

A mutation in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS)
and frontotemporal dementia (FTD). Patients with ALS or FTD often develop autoimmunity …

A repeat expansion mutation in the C9orf72 gene is the leading known genetic cause of FTD
and ALS. The C9orf72-ALS/FTD field has been plagued by a lack of reliable tools to monitor …

Efforts to genetically reverse C9orf72 pathology have been hampered by our incomplete
understanding of the regulation of this complex locus. We generated five different genomic …

Abstract Amyotrophic Lateral Sclerosis (ALS), like many other neurodegenerative diseases,
is highly heritable, but with only a small fraction of cases explained by monogenic disease …

Animal or human models recapitulating brain ribosomopathies are incomplete, hampering
development of urgently needed therapies. Here, we generated genetic mouse and human …