A century ago, Otto Heinrich Warburg made a seminal discovery now known as the Warburg
effect. This metabolic signature, prevalent across all cancer cells, is characterized by the …

Itaconate is a metabolite that synthesized from cis-aconitate in mitochondria and transported
into the cytosol to exert multiple regulatory effects in macrophages. However, the …

Metabolism includes anabolism and catabolism, which play an essential role in many
biological processes. Chromatin modifications are post‐translational modifications of …

Itaconate inhibits CD103+ TRM cells and alleviates hepatobil... : Hepatology Itaconate inhibits
CD103+ TRM cells and alleviates hepatobiliary injury in mouse models of primary sclerosing …

The active removal of DNA methylation marks is governed by the ten-eleven translocation
(TET) family of enzymes (TET1–3), which iteratively oxidize 5-methycytosine (5mC) into 5 …

Background Macrophages are innate immune cells whose phagocytosis function is critical to
the prognosis of stroke and peritonitis. cis-aconitic decarboxylase immune-responsive gene …

Efferocytosis and metabolic reprogramming of macrophages play crucial roles in myocardial
infarction (MI) repair. TREM2 has been proven to participate in phagocytosis and …

Polyguluronate (PG) is a fermentable polysaccharide from edible algae. The present study
was designed to investigate the therapeutic effect of PG on ulcerative colitis (UC) and its …

The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to
clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral …

Macrophage-orchestrated inflammation contributes to multiple diseases including sepsis.
However, the underlying mechanisms remain to be defined clearly. Here, we show that …