Emerging epigenetic insights into aging mechanisms and interventions
Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …
still an evolving field with much to explore, it has rapidly gained significance by providing …
Pterostilbene in the treatment of inflammatory and oncological diseases
P Liu, W Tang, K Xiang, G Li - Frontiers in Pharmacology, 2024 - frontiersin.org
Pterostilbene (PTS), a naturally occurring analog of resveratrol (RSV), has garnered
significant attention due to its potential therapeutic effects in treating inflammatory and …
significant attention due to its potential therapeutic effects in treating inflammatory and …
Low-input and single-cell methods for Infinium DNA methylation BeadChips
Abstract The Infinium BeadChip is the most widely used DNA methylome assay technology
for population-scale epigenome profiling. However, the standard workflow requires over 200 …
for population-scale epigenome profiling. However, the standard workflow requires over 200 …
[HTML][HTML] Cell-type-specific effects of age and sex on human cortical neurons
Altered transcriptional and epigenetic regulation of brain cell types may contribute to
cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation …
cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation …
[HTML][HTML] Aging clocks based on accumulating stochastic variation
DH Meyer, B Schumacher - Nature Aging, 2024 - nature.com
Aging clocks have provided one of the most important recent breakthroughs in the biology of
aging, and may provide indicators for the effectiveness of interventions in the aging process …
aging, and may provide indicators for the effectiveness of interventions in the aging process …
Epigenetic predictors of species maximum life span and other life-history traits in mammals
By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation
(DNAm) predictors of maximum life span (R= 0.89), gestation time (R= 0.96), and age at …
(DNAm) predictors of maximum life span (R= 0.89), gestation time (R= 0.96), and age at …
Annelid methylomes reveal ancestral developmental and aging-associated epigenetic erosion across Bilateria
K Guynes, LA Sarre, AM Carrillo-Baltodano, BE Davies… - Genome Biology, 2024 - Springer
Background DNA methylation in the form of 5-methylcytosine (5mC) is the most abundant
base modification in animals. However, 5mC levels vary widely across taxa. While …
base modification in animals. However, 5mC levels vary widely across taxa. While …
Accelerating progress towards the 2030 neglected tropical diseases targets: how can quantitative modeling support programmatic decisions?
A Vasconcelos, JD King, C Nunes-Alves… - Clinical Infectious …, 2024 - academic.oup.com
Over the past decade, considerable progress has been made in the control, elimination, and
eradication of neglected tropical diseases (NTDs). Despite these advances, most NTD …
eradication of neglected tropical diseases (NTDs). Despite these advances, most NTD …
DNA methylation clocks for clawed frogs reveal evolutionary conservation of epigenetic aging
To address how conserved DNA methylation-based epigenetic aging is in diverse branches
of the tree of life, we generated DNA methylation data from African clawed frogs (Xenopus …
of the tree of life, we generated DNA methylation data from African clawed frogs (Xenopus …
MammalMethylClock R package: software for DNA methylation-based epigenetic clocks in mammals
Motivation Epigenetic clocks are prediction methods based on DNA methylation levels in a
given species or set of species. Defined as multivariate regression models, these DNA …
given species or set of species. Defined as multivariate regression models, these DNA …