Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis

C Bei, J Zhu, PH Culviner, M Gan, EJ Rubin… - Nature …, 2024 - nature.com
Transcriptional regulation is a critical adaptive mechanism that allows bacteria to respond to
changing environments, yet the concept of transcriptional plasticity (TP)–the variability of …

Harnessing regulatory networks in Actinobacteria for natural product discovery

HE Augustijn, AM Roseboom… - Journal of Industrial …, 2024 - academic.oup.com
Microbes typically live in complex habitats, where they need to rapidly adapt to continuously
changing growth conditions. To do so, they produce an astonishing array of natural products …

Structural and biophysical characterization of PadR family protein Rv1176c of Mycobacterium tuberculosis H37Rv

V Yadav, M Zohib, S Singh, RK Pal, S Tripathi… - International Journal of …, 2024 - Elsevier
Rv1176c of Mycobacterium tuberculosis H37Rv belongs to the PadR-s1 subfamily of the
PadR family of protein. Rv1176c forms a stable dimer in solution. Its stability is characterized …

MLDSR, the transcriptional regulator of the major lipid droplets protein MLDS, is controlled by long‐chain fatty acids and contributes to the lipid‐accumulating …

MA Hernández, AE Ledesma, G Moncalián… - The FEBS …, 2024 - Wiley Online Library
Microorganism lipid droplet small regulator (MLDSR) is a transcriptional regulator of the
major lipid droplet (LD)‐associated protein MLDS in Rhodococcus jostii RHA1 and …

Structural insights into the regulation mechanism of Mycobacterium tuberculosis MftR

F Peng, Z Ke, H Jin, W Wang, H Zhang… - The FASEB …, 2024 - Wiley Online Library
Mycobacterium tuberculosis, the pathogen of the deadly disease tuberculosis, depends on
the redox cofactor mycofactocin (MFT) to adapt to and survive under hypoxic conditions …

Signal-independent activation reveals two-component regulatory networks

C Claverie, F Coppolino, MV Mazzuoli, C Guyonnet… - bioRxiv, 2024 - biorxiv.org
Each bacterial species has specific regulatory systems to control physiology, adaptation,
and host interactions. One challenge posed by this diversity is to define the evolving gene …

Predictive Biophysical Neural Network Modeling of a Compendium of in vivo Transcription Factor DNA Binding Profiles for Escherichia coli

P Lally, L Gómez-Romero, VH Tierrafría, P Aquino… - bioRxiv, 2024 - biorxiv.org
The DNA binding of most Escherichia coli Transcription Factors (TFs) has not been
comprehensively mapped, and few have models that can quantitatively predict binding …

Elucidation of an essential genetic pathway under antibiotic selection in Mycobacterium tuberculosis

YJ Liu - 2024 - dash.harvard.edu
Tuberculosis remains the world's deadliest infectious disease caused by a single agent.
Although tuberculosis is curable, treatment success is limited by our narrow understanding …