Scalable single-cell profiling of chromatin modifications with sciCUT&Tag
DH Janssens, JE Greene, SJ Wu, CA Codomo… - Nature …, 2024 - nature.com
Cleavage under targets and tagmentation (CUT&Tag) is an antibody-directed in situ
chromatin profiling strategy that is rapidly replacing immune precipitation-based methods …
chromatin profiling strategy that is rapidly replacing immune precipitation-based methods …
[HTML][HTML] Dictionary learning for integrative, multimodal and scalable single-cell analysis
Mapping single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …
powerful alternative to unsupervised analysis. However, most reference datasets are …
[HTML][HTML] Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy
M Wang, Y Liu, R Sun, F Liu, J Li, L Yan, J Zhang… - Nature Genetics, 2024 - nature.com
The human placenta has a vital role in ensuring a successful pregnancy. Despite the
growing body of knowledge about its cellular compositions and functions, there has been …
growing body of knowledge about its cellular compositions and functions, there has been …
A single-cell atlas of chromatin accessibility in mouse organogenesis
Organogenesis is a highly complex and precisely regulated process. Here we profiled the
chromatin accessibility in> 350,000 cells derived from 13 mouse embryos at four …
chromatin accessibility in> 350,000 cells derived from 13 mouse embryos at four …
Mapping the chromatin accessibility landscape of zebrafish embryogenesis at single-cell resolution by SPATAC-seq
Currently, the dynamic accessible elements that determine regulatory programs responsible
for the unique identity and function of each cell type during zebrafish embryogenesis lack …
for the unique identity and function of each cell type during zebrafish embryogenesis lack …
[HTML][HTML] An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
Abstract Analysis of the human hematopoietic progenitor compartment is being transformed
by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by …
by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by …
Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles
Translating genome-wide association study (GWAS) loci into causal variants and genes
requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues …
requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues …
[HTML][HTML] Decoding leukemia at the single-cell level: clonal architecture, classification, microenvironment, and drug resistance
Leukemias are refractory hematological malignancies, characterized by marked intrinsic
heterogeneity which poses significant obstacles to effective treatment. However, traditional …
heterogeneity which poses significant obstacles to effective treatment. However, traditional …
TIM-3+ CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies
Chronic antigen stimulation is thought to generate dysfunctional CD8 T cells. Here, we
identify a CD8 T cell subset in the bone marrow tumor microenvironment that, despite an …
identify a CD8 T cell subset in the bone marrow tumor microenvironment that, despite an …
Convergent epigenetic evolution drives relapse in acute myeloid leukemia
Relapse of acute myeloid leukemia (AML) is highly aggressive and often treatment
refractory. We analyzed previously published AML relapse cohorts and found that 40% of …
refractory. We analyzed previously published AML relapse cohorts and found that 40% of …