The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …

Computational models that measure biological age and aging rate regardless of
chronological age are called aging clocks. The underlying counting mechanisms of the …

DNA methylation (DNAm)-based age clocks have been studied extensively as a biomarker
of human ageing and a risk factor for age-related diseases. Despite different tissues having …

Young blood plasma is known to confer beneficial effects on various organs in mice and
rats. However, it was not known whether plasma from young adult pigs rejuvenates old rat …

Objective Short sleep and insomnia are each associated with a greater risk of age-related
disease, which suggests that insufficient sleep may accelerate biological aging. We examine …

DNA methylation clocks can accurately estimate chronological age and, to some extent, also
biological age, yet the process by which age-associated DNA methylation (DNAm) changes …

Altered transcriptional and epigenetic regulation of brain cell types may contribute to
cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation …

Background There is divergence in the rate at which people age. The concept of biological
age is postulated to capture this variability, and hence to better represent an individual's true …

Sex hormones are hypothesized to drive sex-specific health disparities. Here, we study the
association between sex steroid hormones and DNA methylation-based (DNAm) biomarkers …

Age-related changes in DNA methylation (DNAm) form the basis of the most robust
predictors of age—epigenetic clocks—but a clear mechanistic understanding of exactly …