[HTML][HTML] Pulmonary inhalation for disease treatment: Basic research and clinical translations

B Wang, L Wang, Q Yang, Y Zhang, T Qinglai, X Yang… - Materials Today Bio, 2024 - Elsevier
Pulmonary drug delivery has the advantages of being rapid, efficient, and well-targeted, with
few systemic side effects. In addition, it is non-invasive and has good patient compliance …

COVID‐19 cooling: Nanostrategies targeting cytokine storm for controlling severe and critical symptoms

Y Zheng, Y Li, M Li, R Wang, Y Jiang… - Medicinal Research …, 2024 - Wiley Online Library
As severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants continue to
wreak havoc worldwide, the “Cytokine Storm”(CS, also known as the inflammatory storm) or …

Understanding the impact of mannitol on physical stability and aerosolization of spray-dried protein powders for inhalation

KS Arte, CW Tower, TT Mutukuri, Y Chen… - International Journal of …, 2024 - Elsevier
Pulmonary delivery of protein-based therapeutics, including antibodies, is a promising
option for treating respiratory diseases. Spray drying is a widely used method for producing …

Validation of the Absorption-Enhancing Ability of Oligoarginines Grafted onto a Backbone of Hyaluronic Acid through Animal Studies from Rodents to Primates

H Yagi, T Tomono, K Abe, Y Tsutsumi… - Molecular …, 2024 - ACS Publications
The purpose of our research is to develop functional additives that enhance mucosal
absorption of biologics, such as peptide/protein and antibody drugs, to provide their non-to …

Use of Closed System Transfer Devices (CSTDs) with Protein-Based Therapeutic Drugs—A Non-Solution for a Non-Problem?

J Fast, T Christian, M Crul, W Jiskoot… - Journal of …, 2024 - jpharmsci.org
The authors want to acknowledge the AAPS Communities to providing a space for the DP
Handling Community that encouraged the writing of this paper. We also want to …

[HTML][HTML] Distribution and suitability of pulmonary surfactants as a vehicle for topically applied antibodies in healthy and SARS-CoV-2 infected rodent lungs

LA Barlang, I Deimel, BP Mohl, C Blaurock… - European Journal of …, 2024 - Elsevier
The use of natural pulmonary surfactants (PS) as a drug delivery vehicle for biologics is a
more recent therapeutic modality. Herein, we tested different contents of PS regarding their …

[HTML][HTML] High-loading cannabidiol powders for inhalation

W Tai, GTY Yau, JC Arnold, HK Chan… - International Journal of …, 2024 - Elsevier
Limited attempts have been made previously to develop high-loading CBD inhalable
powders, which are essential for high dose delivery. Therefore, this study aimed to develop …

Efficient Nebulization and Pulmonary Biodistribution of Polymeric Nanocarriers in an Acute Lung Injury Preclinical Model

A Solé‐Porta, A Areny‐Balagueró… - Small …, 2024 - Wiley Online Library
Acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by acute
hypoxemic respiratory failure. Pneumonia and sepsis are the most common causes, turning …

Molecular Imaging for Lung Cancer: Exploring Small Molecules, Peptides, and Beyond in Radiolabeled Diagnostics

M Ekinci, TM Magne, LMR Alencar, PBA Fechine… - Pharmaceutics, 2024 - mdpi.com
It is evident that radiolabeled drug delivery systems hold great promise in the field of lung
cancer management. The combination of therapeutic agents with radiotracers not only …

Advances in Pulmonary Protein Delivery Systems

Y Zhao, S Liu, X Lu - Advanced NanoBiomed Research, 2024 - Wiley Online Library
Protein‐based therapeutics and vaccines play a pivotal role in the realm of biomedical
science. Pulmonary administration offers several advantages including rapid adsorption …