The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …

Molecular mechanisms of organismal and cell aging remain incompletely understood. We,
therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 …

Recently, biological aging has been quantified in DNA-methylation samples of older adults
and applied as so-called “methylation profile scores”(MPSs) in separate target samples …

Sleep is a modifiable behavior that can be targeted in interventions aimed at promoting
healthy aging. This study aims to (i) identify the sleep duration trend in US adults;(ii) …

Exercise training prevents age‐related decline in muscle function. Targeting epigenetic
aging is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging …

A central prediction of evolutionary theory is that energy invested into reproduction comes at
the expense of somatic maintenance and repair, accelerating biological aging. Supporting …

Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …

Survivors of childhood cancer may experience accelerated biological aging, resulting in
premature frailty and death. We used seven measures of biological age in the St. Jude …

The goal of this study is to examine the association between in utero drought exposure and
epigenetic age acceleration (EAA) in a global climate change hot spot. Calculations of EAA …

Females live longer than males, and there are sex disparities in physical health and disease
incidence. However, sex differences in biological aging have not been consistently reported …