Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

Aging is accompanied by alterations in the body with time-related to decline of physiological
integrity and functionality process, responsible for increasing diseases and vulnerability to …

Background Exercise training promotes brain plasticity and is associated with protection
against cognitive impairment and Alzheimer's disease (AD). These beneficial effects may be …

Immunosenescence contributes to systematic aging and plays a role in the pathogenesis of
Alzheimer's disease (AD). Therefore, the objective of this study was to investigate the …

There is converging evidence that young blood conveys cells, vesicles, and molecules able
to revitalize function and restore organ integrity in old individuals. We assessed the effects of …

Abstract Alzheimer's disease (AD), the leading cause of dementia, is characterized by the
accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition …

Aging is a complex process characterized by a myriad of physiological changes, including
alterations in the immune system termed immunosenescence. It exerts profound effects on …

As people age, their ability to resist injury and repair damage decreases significantly.
Platelet-rich plasma (PRP) has demonstrated diverse therapeutic effects on tissue repair …

Our limited understanding of complex neurodegenerative disorders has held us back on the
development of efficient therapies. While several approaches are currently being …

Age-related impairment of neurovascular coupling (NVC;“functional hyperemia”) is a critical
factor in the development of vascular cognitive impairment (VCI). Recent geroscience …