[HTML][HTML] Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents

WO Castillo-Ordoñez, N Cajas-Salazar… - Neural regeneration …, 2024 - journals.lww.com
Alzheimer's disease is a progressive neurodegenerative disorder and the most common
cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative …

[HTML][HTML] Amyloid Precursor Protein: A Regulatory Hub in Alzheimer's Disease

J Chen, JS Chen, S Li, F Zhang, J Deng… - Aging and …, 2024 - ncbi.nlm.nih.gov
Decades of research have demonstrated an incontrovertible role of amyloid-β (Aβ) in the
etiology of Alzheimer's disease (AD). However, the overemphasis on the pathological …

MESPool: Molecular Edge Shrinkage Pooling for hierarchical molecular representation learning and property prediction

F Xu, Z Yang, L Wang, D Meng… - Briefings in …, 2024 - academic.oup.com
Identifying task-relevant structures is important for molecular property prediction. In a graph
neural network (GNN), graph pooling can group nodes and hierarchically represent the …

Screening Techniques for Drug Discovery in Alzheimer's Disease

S Maniam, S Maniam - ACS omega, 2024 - ACS Publications
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive and
irreversible impairment of memory and other cognitive functions of the aging brain …

[HTML][HTML] Constituents, pharmacological activities, pharmacokinetic studies, clinical applications, and safety profile on the classical prescription Kaixinsan

L Chen, L Jiang, X Shi, J Yang, R Wang… - Frontiers in …, 2024 - frontiersin.org
Kaixinsan (KXS) is a noteworthy classical prescription, which consists of four Chinese
medicinal herbs, namely Polygalae Radix, Ginseng Radix et Rhizoma, Poria, and Acori …

Quercetin-3-O-glc-1-3-rham-1-6-glucoside decreases Aβ production, inhibits Aβ aggregation and neurotoxicity, and prohibits the production of inflammatory cytokines

S Tan, L Wu, J Liu, Z Wu, Q Cheng, Q Qu, L Zhu… - European Journal of …, 2024 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease with the hallmark of
aggregation of beta-amyloid (Aβ) into extracellular fibrillar deposition. Accumulating …

New Insights into Butyrylcholinesterase: Pharmaceutical Applications, Selective Inhibitors and Multitarget-Directed Ligands

T Sun, T Zhen, CH Harakandi, L Wang, H Guo… - European Journal of …, 2024 - Elsevier
Butyrylcholinesterase (BChE), also known as pseudocholinesterase and serum
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …

Navigating the Maze of Alzheimer's Disease by Exploring BACE1: Discovery, Current Scenario, and Future Prospects

F Iram, M Shahid, J Ansari, GM Ashraf… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) is a chronic neurological condition that has become a leading
cause of cognitive decline in elder individuals. Hardly any effective medication has been …

Current trends and updates in the treatment of Alzheimer's disease

NH Parikh, PK Parikh, HJ Rao, K Shah, BP Dave… - Alzheimer's Disease and …, 2024 - Elsevier
Alzheimer's disease (AD) is one the most prevalent multifactorial neurodegenerative
ailments of aging and is the leading cause of cognitive deficits with progressive impairment …

[HTML][HTML] Targeting the molecular web of Alzheimer's disease: unveiling pathways for effective pharmacotherapy

D Jadhav, N Saraswat, N Vyawahare… - The Egyptian Journal of …, 2024 - Springer
Introduction Alzheimer's disease is a neurocognitive disorder that affects elderly people by
slowly impaired cognition, dementia, and gets worse with age. It slowly impacts the quality of …