Aging is characterized by an alteration of several physiological processes and biological
pathways that leads to an increased susceptibility to age-related diseases and death …

Immunosenescence increases the risk and severity of diseases in elderly individuals and
leads to impaired vaccine-induced immunity. With aging of the global population and the …

Weakened germinal center responses by the aged immune system result in diminished
immunity against pathogens and reduced efficacy of vaccines. Prolonged contacts between …

Investigational therapeutics that target toxic species of α-synuclein (αSyn) aim to slow down
or halt disease progression in patients with Parkinson's disease (PD). Here this 44-week …

Age is associated with reduced efficacy of vaccines and linked to higher risk of severe
COVID-19. Here we determined the impact of ageing on the efficacy of a SARS-CoV-2 …

It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …

Defective host defenses later in life are associated with changes in immune cell activities,
suggesting that age-specific considerations are needed in immunotherapy approaches. In …

Factors associated with shingles and pneumococcal vaccination among older Canadians Page
1 Health Reports Catalogue no. 82-003-X ISSN 1209-1367 by Heather Gilmour Factors …

Respiratory viral infections frequently lead to severe respiratory disease, particularly in
vulnerable populations such as young children, individuals with chronic lung conditions and …

The development of vaccines has drastically reduced the mortality and morbidity of several
diseases. Despite the great success of vaccines, the immunological processes involved in …