The tumor microenvironment (TME) constitutes a complex microenvironment comprising a
diverse array of immune cells and stromal components. Within this intricate context, tumor …

The organization of immune cells in human tumors is not well understood. Immunogenic
tumors harbor spatially localized multicellular 'immunity hubs' defined by expression of the T …

Many mechanisms underlying an effective immunotherapy-induced antitumour response are
transient and critically time dependent. This is equally true for several immunological events …

Understanding the role of the tumor microenvironment (TME) in lung cancer is critical to
improving patient outcomes. We identified four histology-independent archetype TMEs in …

Total tumor clearance through immunotherapy is associated with a fully coordinated innate
and adaptive immune response, but knowledge on the exact contribution of each immune …

Major histocompatibility complex (MHC) class I antigen presentation deficiency is a common
cancer immune escape mechanism, but the mechanistic implications and potential …

Adding anti–programmed cell death protein 1 (anti–PD-1) to 5-fluorouracil (5-FU)/platinum
improves survival in some advanced gastroesophageal adenocarcinomas (GEA). To …

The redirection of T cells has emerged as an attractive therapeutic principle in B cell non-
Hodgkin lymphoma (B-NHL). However, a detailed characterization of lymphoma-infiltrating T …

Receptors controlling the cross-presentation of tumor antigens by macrophage subsets in
cancer tissues are poorly explored. Here, we show that TIM4+ large peritoneal …

Tumor progression is accompanied by fibrosis, a condition of excessive extracellular matrix
accumulation, which is associated with diminished antitumor immune infiltration. Here we …