Approximately 65 million adults globally have heart failure, and the prevalence is expected
to increase substantially with ageing populations. Despite advances in pharmacological and …

End-stage organ failure can result from various preexisting conditions and occurs in patients
of all ages, and organ transplantation remains its only treatment. In recent years, extensive …

Extensive studies on HIV-1 have led to the discovery of a variety of structurally and
functionally diverse innate defense factors that target various steps of the retroviral …

Xenotransplantation holds great promise as a solution to address the critical shortage of
organs, but it raises concerns regarding the potential transmission of porcine viruses to …

The applicability of cytosine base editors is hindered by their dependence on sequence
context and by off-target effects. Here, by using AlphaFold2 to predict the three-dimensional …

An estimated 1.5 million Americans suffer from Type I diabetes mellitus, and its incidence is
increasing worldwide. Islet allotransplantation offers a treatment, but the availability of …

In this state-of-the-art review we detail the journey of xenotransplantation from its infancy,
detailing one of the first published cases and the subsequent journey the field took in its …

In this clinicopathological conference, invited experts discussed a previously published case
of a patient with nonischemic cardiomyopathy who underwent heart transplantation from a …

Because there is a shortage of donor kidneys, researchers are exploring the possibility of
using genetically modified pig kidneys for transplantation. Approaches involving knockout of …

Hereditary hearing loss (HHL), a genetic disorder that impairs auditory function, significantly
affects quality of life and incurs substantial economic losses for society. To investigate the …