Immunophenotypes in psychosis: is it a premature inflamm-aging disorder?

S Chen, Y Tan, L Tian - Molecular Psychiatry, 2024 - nature.com
Immunopsychiatric field has rapidly accumulated evidence demonstrating the involvement of
both innate and adaptive immune components in psychotic disorders such as …

Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia

G Livshits, A Kalinkovich - Ageing Research Reviews, 2024 - Elsevier
Sarcopenia is an age-associated loss of skeletal muscle mass, strength, and function,
accompanied by severe adverse health outcomes, such as falls and fractures, functional …

[PDF][PDF] Neuroinflammaging: A tight line between normal aging and age-related neurodegenerative disorders

L Soraci, A Corsonello, E Paparazzo, A Montesanto… - Aging Dis, 2024 - researchgate.net
Aging in the healthy brain is characterized by a low-grade, chronic, and sterile inflammatory
process known as neuroinflammaging. This condition, mainly consisting in an up-regulation …

Vocal fold fibroblasts and exposure to vibration in vitro: Does sex matter?

A Kirsch, T Grossmann, B Steffan, A Groselj-Strele… - Plos one, 2024 - journals.plos.org
Studies have shown that certain vocal fold pathologies are more common in one sex than
the other. This is often explained by differences in the composition of the lamina propria and …

GlycA and CRP Are Genetically Correlated: Insight into the Genetic Architecture of Inflammageing

M Kasher, MB Freidin, FMK Williams, G Livshits… - Biomolecules, 2024 - mdpi.com
Inflammageing is a condition of perpetual low-grade inflammation induced by ageing.
Inflammageing may be predicted by the C-reactive protein (CRP) or by a recently described …

Evolution of innate immunity: lessons from mammalian models shaping our current view of insect immunity

RCMC Silva, IB Ramos, LH Travassos… - Journal of Comparative …, 2024 - Springer
The innate immune system, a cornerstone for organismal resilience against environmental
and microbial insults, is highly conserved across the evolutionary spectrum, underpinning its …

[HTML][HTML] Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis

RS Blanc, N Shah, NAS Salama, FW Meng… - Research …, 2024 - ncbi.nlm.nih.gov
Aging is associated with a decline in stem cell functionality and number across the
organism. In this study, we aimed to further unravel Muscle Stem Cells (MuSCs) aging by …

Changes in microglia chromatin accessibility in aged female mice.

VA Ansere, KB Tooley, K Srividya, W Hoolehan… - bioRxiv, 2024 - biorxiv.org
Aged female microglia display a more inflammatory and disease-associated phenotype
compared to age-matched males. Epigenetic mechanisms, such as chromatin accessibility …