[HTML][HTML] Molecular insights into the adaptive evolution of SARS-CoV-2 spike protein
Z Yao, L Zhang, Y Duan, X Tang, J Lu - Journal of Infection, 2024 - Elsevier
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has substantially damaged the global economy and human health. The …
(SARS-CoV-2), has substantially damaged the global economy and human health. The …
SARS-CoV-2 resistance to monoclonal antibodies and small-molecule drugs
S Iketani, DD Ho - Cell Chemical Biology, 2024 - cell.com
Over four years have passed since the beginning of the COVID-19 pandemic. The scientific
response has been rapid and effective, with many therapeutic monoclonal antibodies and …
response has been rapid and effective, with many therapeutic monoclonal antibodies and …
A third dose of inactivated vaccine augments the potency, breadth, and duration of anamnestic responses against SARS-CoV-2
Z Jia, K Wang, M Xie, J Wu, Y Hu, Y Zhou… - Protein & …, 2024 - academic.oup.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) has lasted for more than four years …
respiratory syndrome coronavirus-2 (SARS-CoV-2) has lasted for more than four years …
The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA. 2.86
Under pressure from neutralising antibodies induced by vaccination or infection the SARS-
CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all …
CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all …
Emerging variants develop total escape from potent monoclonal antibodies induced by BA. 4/5 infection
The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody
response in the face of high levels of immunity. Here, we isolate spike (S) binding …
response in the face of high levels of immunity. Here, we isolate spike (S) binding …
A structure-function analysis shows SARS-CoV-2 BA. 2.86 balances antibody escape and ACE2 affinity
Summary BA. 2.86, a recently described sublineage of SARS-CoV-2 Omicron, contains
many mutations in the spike gene. It appears to have originated from BA. 2 and is distinct …
many mutations in the spike gene. It appears to have originated from BA. 2 and is distinct …
Mutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/Tetherin
Y Shi, S Simpson, Y Chen, H Aull, J Benjamin… - Plos …, 2024 - journals.plos.org
BST2/Tetherin is a restriction factor with broad antiviral activity against enveloped viruses,
including coronaviruses. Specifically, BST2 traps nascent particles to membrane …
including coronaviruses. Specifically, BST2 traps nascent particles to membrane …
Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain
RS Sankhala, V Dussupt, WH Chen, H Bai, EJ Martinez… - Structure, 2024 - cell.com
Given the continuous emergence of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variants of concern (VoCs), immunotherapeutics that target conserved …
(SARS-CoV-2) variants of concern (VoCs), immunotherapeutics that target conserved …
An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial
Here we conducted a multicenter open-label, randomized phase 2 and 3 study to assess the
safety and immunogenicity of a severe acute respiratory syndrome coronavirus 2 (SARS …
safety and immunogenicity of a severe acute respiratory syndrome coronavirus 2 (SARS …
[HTML][HTML] Stronger and durable SARS-CoV-2 immune response to mRNA vaccines in 5–11 years old children with prior COVID-19
C Di Chiara, A Cantarutti, MR Petrara, F Bonfante… - Vaccine, 2024 - Elsevier
Background and objectives mRNA vaccines elicit a durable humoral response to SARS-CoV-
2 in adults, whereas evidence in children is scarce. This study aimed to assess the early and …
2 in adults, whereas evidence in children is scarce. This study aimed to assess the early and …