Metabolic bioactivation of antidepressants: advance and underlying hepatotoxicity

SM Khalil, KR MacKenzie… - Drug Metabolism …, 2024 - Taylor & Francis
Many drugs that serve as first-line medications for the treatment of depression are
associated with severe side effects, including liver injury. Of the 34 antidepressants …

Cyanide Trapping of Iminium Ion Reactive Metabolites: Implications for Clinical Hepatotoxicity

X Miao, GJ Dear, C Beaumont, G Vitulli… - Chemical Research …, 2024 - ACS Publications
Reactive metabolite formation is a major mechanism of hepatotoxicity. Although reactive
electrophiles can be soft or hard in nature, screening strategies have generally focused on …

A One‐Pot Synthesized Chemodosimetric Chemosensor for Highly Sensitive Cyanide Ion Detection in Aqueous Media and from Tobacco Smoke

PS Umabharathi, P Purushothaman… - …, 2024 - Wiley Online Library
A sustainable future world consistently attributes to the development of eco‐friendly methods
and materials for detection and elimination of toxic substances from the environment. While …