We present a major update of the HOCOMOCO collection that provides DNA binding
specificity patterns of 949 human transcription factors and 720 mouse orthologs. To make …

Myeloproliferative neoplasms (MPNs) are chronic cancers characterized by overproduction
of mature blood cells. Their causative somatic mutations, for example, JAK2 V617F, are …

Bulk-tissue molecular quantitative trait loci (QTLs) have been the starting point for
interpreting disease-associated variants, and context-specific QTLs show particular …

Preclinical evidence implicating cannabinoid receptor 2 (CB2) in various diseases has led
researchers to question whether CB2 genetics influence aetiology or progression …

We assessed the causal relation of four glycemic traits and type 2 diabetes liability with 167
metabolites using Mendelian randomization with various sensitivity analyses and a reverse …

Although genome-wide association studies (GWAS) have successfully linked genetic risk
loci to various disorders, identifying underlying cellular biological mechanisms remains …

Periodontitis drives irreversible destruction of periodontal tissue and is prone to
exacerbating inflammatory disorders. Systemic immunomodulatory management continues …

Observational studies have previously reported an association between depression and
certain female reproductive disorders. However, the causal relationships between …

Background Obesity is a metabolic and chronic inflammatory disease involving genetic and
environmental factors. This study aimed to investigate the causal relationship among gut …

Autoimmune Addison's disease (AAD) is a rare but life-threatening endocrine disorder
caused by an autoimmune destruction of the adrenal cortex. A previous genome-wide …