Cellular senescence occurs in response to endogenous or exogenous stresses and is
characterized by stable cell cycle arrest, alterations in nuclear morphology and secretion of …

Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases,
including multiple sclerosis and experimental autoimmune encephalomyelitis,,,,,,–(EAE), an …

The aging process has been one of the most necessary research fields in the current
century, and knowing different theories of aging and the role of different genetic, epigenetic …

Chemical discovery efforts commonly target individual protein domains. Many proteins,
including the EP300/CBP histone acetyltransferases (HATs), contain several targetable …

Access to DNA is the first level of control in regulating gene transcription, a control that is
also critical for maintaining DNA integrity. Cellular senescence is characterized by profound …

We identify a senescence restriction point (SeRP) as a critical event for cells to commit to
senescence. The SeRP integrates the intensity and duration of oncogenic stress, keeps a …

Exercise has the unique aptitude to benefit overall health of body and brain. Evidence
indicates that the effects of exercise can be saved in the epigenome for considerable time to …

Epigenetic changes have been established to be a hallmark of aging, which implies that
aging science requires collaborating with the field of chromatin biology. DNA methylation …

Cardiovascular disease is a main cause of mortality in the world and the highest incidence
of all diseases. However, the mechanism of the pathogenesis of cardiovascular disease is …

Cell senescence is an anti-cancer strategy following DNA repair and apoptosis, which is
associated with the initiation, progression, and treatment of ovarian cancer. The CDK4/6 …