The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …

Abstract Background and Aims Lipoprotein (a)(Lp [a]) is an established risk factor for
atherosclerotic cardiovascular disease (ASCVD). However, data on association of Lp (a) …

The cost of drug discovery and development is driven primarily by failure, with only about
10% of clinical programmes eventually receiving approval,–. We previously estimated that …

Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most
prevalent in Northern Europe. Although it is known that inherited risk for MS is located within …

Translating genome-wide association study (GWAS) loci into causal variants and genes
requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues …

Abstract The Holocene (beginning around 12,000 years ago) encompassed some of the
most significant changes in human evolution, with far-reaching consequences for the …

Lyme disease is a tick-borne disease caused by bacteria of the genus Borrelia. The host
factors that modulate susceptibility for Lyme disease have remained mostly unknown. Using …

Dysfunction of brain resting-state functional networks has been widely reported in
psychiatric disorders. However, the causal relationships between brain resting-state …

Importance Lower educational attainment is associated with increased risk of adverse
pregnancy outcomes, but it is unclear which pathways mediate this association. Objective To …

Anxiety disorders are the most prevalent mental disorders. However, the genetic etiology of
anxiety disorders remains largely unknown. Here we conducted a genome-wide meta …