New advances in the pharmacology and toxicology of lithium: a neurobiologically oriented overview
Over the last six decades, lithium has been considered the gold standard treatment for the
long-term management of bipolar disorder due to its efficacy in preventing both manic and …
long-term management of bipolar disorder due to its efficacy in preventing both manic and …
Recent advances in the development of P2Y14R inhibitors: a patent and literature review (2018-present)
K Wang, F Zhong, ZD Zhang, HQ Li… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction The P2Y14 receptor (P2Y14R), a member of the G protein-coupled
receptor family, is activated by extracellular nucleotides. Due to its involvement in …
receptor family, is activated by extracellular nucleotides. Due to its involvement in …
Identification of novel NLRP3 inhibitors as therapeutic options for epilepsy by machine learning-based virtual screening, molecular docking and biomolecular …
M Zulfat, MA Hakami, AM Hazazi, A Mahmood… - Heliyon, 2024 - cell.com
The NOD-Like Receptor Protein-3 (NLRP3) inflammasome is a key therapeutic target for the
treatment of epilepsy and has been reported to regulate inflammation in several …
treatment of epilepsy and has been reported to regulate inflammation in several …
Optimization of virtual screening against phosphoinositide 3-kinase delta: Integration of common feature pharmacophore and multicomplex-based molecular docking
J Zhu, H Meng, X Li, L Jia, L Xu, Y Cai, Y Chen… - … Biology and Chemistry, 2024 - Elsevier
Extensive research has accumulated which suggests that phosphatidylinositol 3-kinase
delta (PI3Kδ) is closely related to the occurrence and development of various human …
delta (PI3Kδ) is closely related to the occurrence and development of various human …
Prospective virtual screening combined with bio-molecular simulation enabled identification of new inhibitors for the KRAS drug target
A Ajmal, HA Alkhatabi, RM Alreemi, MA Alamri… - BMC chemistry, 2024 - Springer
Lung cancer is a disease with a high mortality rate and it is the number one cause of cancer
death globally. Approximately 12–14% of non-small cell lung cancers are caused by …
death globally. Approximately 12–14% of non-small cell lung cancers are caused by …
In Silico Prediction of New Inhibitors for Kirsten Rat Sarcoma G12D Cancer Drug Target Using Machine Learning-Based Virtual Screening, Molecular Docking, and …
A Ajmal, M Danial, M Zulfat, M Numan, S Zakir… - Pharmaceuticals, 2024 - mdpi.com
Single-point mutations in the Kirsten rat sarcoma (KRAS) viral proto-oncogene are the most
common cause of human cancer. In humans, oncogenic KRAS mutations are responsible for …
common cause of human cancer. In humans, oncogenic KRAS mutations are responsible for …
Integration of Multicomplex‐Based Pharmacophore Modeling and Molecular Docking in Machine Learning‐Based Virtual Screening: Toward the Discovery of Novel …
S Qiu, L Jia, S Yuan, Y Cai, Y Chen… - Advanced Theory …, 2024 - Wiley Online Library
Abstract The phosphatidylinositol‐3 kinase (PI3K) pathway is a crucial intracellular signaling
pathway within living cells. The hyperactivation of PI3K signaling cascades is a common …
pathway within living cells. The hyperactivation of PI3K signaling cascades is a common …
Identification of novel covalent JAK3 inhibitors through consensus scoring virtual screening: integration of common feature pharmacophore and covalent docking
G Qiu, L Yu, L Jia, Y Cai, Y Chen, J Jin, L Xu, J Zhu - Molecular Diversity, 2024 - Springer
Accumulated research strongly indicates that Janus kinase 3 (JAK3) is intricately involved in
the initiation and advancement of a diverse range of human diseases, underscoring JAK3 as …
the initiation and advancement of a diverse range of human diseases, underscoring JAK3 as …
Revolution of Artificial Intelligence in Computational Chemistry Breakthroughs
The field of computational chemistry is one of many sectors that artificial intelligence (AI) has
revolutionized in recent years. Chemists are now more equipped to analyze enormous …
revolutionized in recent years. Chemists are now more equipped to analyze enormous …