Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic
driver mutations in combination with chemotherapy and radiotherapy as well as …

Abstract Lysine‐specific demethylase 1 (LSD1) is a flavin adenine dinucleotide (FAD)
dependent monoamine oxidase (MAO) that erases the mono‐, and dimethylation of histone …

Chromatin modifications are linked with regulating patterns of gene expression, but their
causal role and context-dependent impact on transcription remains unresolved. Here we …

Lysine specific demethylase 1 (LSD1), a transcriptional modulator that represses or
activates target gene expression, is overexpressed in many cancer and causes imbalance in …

Lysine-specific demethylase 1 (LSD1/KDM1A) has emerged as a promising therapeutic
target for treating various cancers (such as breast cancer, liver cancer, etc.) and other …

The telomere repeat-containing RNA (TERRA) forms R-loops to promote homology-directed
DNA synthesis in the alternative lengthening of telomere (ALT) pathway. Here we report that …

Modulation of histone methylation status is regarded as an important mechanism of
epigenetic regulation and has substantial clinical potential for the therapy of diseases …

Abstract Lysine Specific Demethylase 1 (LSD1) has been identified as a chromatin-
modifying enzyme implicated in various cancer pathogeneses, highlighting the potential for …

Histone lysine demethylases (KDMs) regulate eukaryotic gene transcription by catalysing
the removal of methyl groups from histone proteins. These enzymes are intricately regulated …

Histone lysine-specific demethylase 1 (LSD1) expression has been evaluated in multiple
tumors, including gastric cancer (GC). However, the mechanisms underlying LSD1 …