Endo-lysosomal dysfunction in neurodegenerative diseases: Opinion on current progress and future direction in the use of exosomes as biomarkers
M Herman, GW Randall, JL Spiegel… - … of the Royal …, 2024 - royalsocietypublishing.org
Over the past two decades, increased research has highlighted the connection between
endosomal trafficking defects and neurodegeneration. The endo-lysosomal network is an …
endosomal trafficking defects and neurodegeneration. The endo-lysosomal network is an …
Clusterin is a potential therapeutic target in Alzheimer's disease
N Palihati, Y Tang, Y Yin, D Yu, G Liu, Z Quan… - Molecular …, 2024 - Springer
In recent years, Clusterin, a glycosylated protein with multiple biological functions, has
attracted extensive research attention. It is closely associated with the physiological and …
attracted extensive research attention. It is closely associated with the physiological and …
Gene-SGAN: discovering disease subtypes with imaging and genetic signatures via multi-view weakly-supervised deep clustering
Disease heterogeneity has been a critical challenge for precision diagnosis and treatment,
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple …
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple …
iPSC‐derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss
Genetic findings have highlighted key roles for microglia in the pathology of
neurodegenerative conditions such as Alzheimer's disease (AD). A number of mutations in …
neurodegenerative conditions such as Alzheimer's disease (AD). A number of mutations in …
Causal relationship between immune cells and neurodegenerative diseases: a two-sample Mendelian randomisation study
C Tang, X Lei, Y Ding, S Yang, Y Ma, D He - Frontiers in Immunology, 2024 - frontiersin.org
Background There is increasing evidence that the types of immune cells are associated with
various neurodegenerative diseases. However, it is currently unclear whether these …
various neurodegenerative diseases. However, it is currently unclear whether these …
Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4‐induced brain pathology
The APOE4 allele is recognized as a significant genetic risk factor to Alzheimer's disease
(AD) and influences longevity. Nonetheless, some APOE4 carriers exhibit resistance to AD …
(AD) and influences longevity. Nonetheless, some APOE4 carriers exhibit resistance to AD …
BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer's disease and other disorders of lipid-rich tissues
A Podleśny-Drabiniok, G Novikova, Y Liu… - Nature …, 2024 - nature.com
Genetic and experimental evidence suggests that Alzheimer's disease (AD) risk alleles and
genes may influence disease susceptibility by altering the transcriptional and cellular …
genes may influence disease susceptibility by altering the transcriptional and cellular …
TrkB-dependent regulation of molecular signaling across septal cell types
LA Rodriguez, MN Tran, R Garcia-Flores, S Oh… - Translational …, 2024 - nature.com
The lateral septum (LS), a GABAergic structure located in the basal forebrain, is implicated
in social behavior, learning, and memory. We previously demonstrated that expression of …
in social behavior, learning, and memory. We previously demonstrated that expression of …
Unraveling the intercellular communication disruption and key pathways in Alzheimer's disease: an integrative study of single-nucleus transcriptomes and genetic …
Background Recently, single-nucleus RNA-seq (snRNA-seq) analyses have revealed
important cellular and functional features of Alzheimer's disease (AD), a prevalent …
important cellular and functional features of Alzheimer's disease (AD), a prevalent …
A Bayesian approach to Mendelian randomization using summary statistics in the univariable and multivariable settings with correlated pleiotropy
Mendelian randomization uses genetic variants as instrumental variables to make causal
inferences on the effect of an exposure on an outcome. Due to the recent abundance of high …
inferences on the effect of an exposure on an outcome. Due to the recent abundance of high …