Resident tissue macrophages (RTMs) encompass a highly diverse set of cells abundantly
present in every tissue and organ. RTMs are recognized as central players in innate immune …

Cardiac macrophages are essential mediators of cardiac development, tissue homeostasis,
and response to injury. Cell-intrinsic shifts in metabolism and availability of metabolites …

Sensory neurons in the dorsal root ganglion (DRG) and trigeminal ganglion (TG) are
specialized to detect and transduce diverse environmental stimuli to the central nervous …

BACKGROUND: Immune checkpoint inhibitors (ICIs), antibodies targeting PD-1
(programmed cell death protein 1)/PD-L1 (programmed death-ligand 1) or CTLA4 (cytotoxic …

Acute myocardial infarction (AMI) is the leading cause of cardiovascular death and remains
the most common cause of heart failure. Reopening of the occluded artery, ie, reperfusion, is …

There is great interest in identifying signaling pathways that promote cardiac repair after
myocardial infarction (MI). Prior studies suggest a beneficial role for IL-13 signaling in …

Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human
disease, which distinguishes the condition from most fibrotic diseases that are progressive …

Permanent fibrosis and chronic deterioration of heart function in patients after myocardial
infarction present a major health-care burden worldwide. In contrast to the restricted …

Rationale: The transition from acute inflammation to fibrosis following myocardial ischemia‒
reperfusion (MIR) significantly affects prognosis. Macrophages play a pivotal role in …

Background & Aims Primary sclerosing cholangitis (PSC) is an immune-mediated
cholestatic liver disease for which there is an unmet need to understand the cellular …