Molecular Basis of Neuronal and Microglial States in the Aging Brain and Impact on Cerebral Blood Vessels

C Maeda, F Tsuruta - International Journal of Molecular Sciences, 2024 - mdpi.com
Brain aging causes a wide variety of changes at the molecular and cellular levels, leading to
the decline of cognitive functions and increased vulnerability to neurodegenerative …

Three-dimensional chromatin reorganization regulates B cell development during ageing

F Ma, Y Cao, H Du, FZ Braikia, L Zong… - Nature Cell …, 2024 - nature.com
The contribution of three-dimensional genome organization to physiological ageing is not
well known. Here we show that large-scale chromatin reorganization distinguishes young …

Exploring the epigenome to identify biological links between the urban environment and neurodegenerative disease: an evidence review

S Glover, C Hill, B McGuinness, AJ McKnight… - Cities & …, 2024 - Taylor & Francis
Global urbanisation has occurred in tandem with population ageing, having implications on
human cognitive health. Urban environmental factors such as air pollution are known risk …

[HTML][HTML] A non-canonical role of ELN protects from cellular senescence by limiting iron-dependent regulation of gene expression

J Czarnecka-Herok, K Zhu, JM Flaman, D Goehrig… - Redox Biology, 2024 - Elsevier
The ELN gene encodes tropoelastin which is used to generate elastic fibers that insure
proper tissue elasticity. Decreased amounts of elastic fibers and/or accumulation of bioactive …

Molecular Basis of Neuronal and Microglial States in the Aging Brain and Impact on Cerebral Blood Vessels

F Tsuruta, C Maeda - 2024 - preprints.org
Brain aging causes a wide variety of changes at molecular and cellular levels, leading to the
decline of cognitive functions and increased vulnerability to neurodegenerative disorders …

Current research on epigenetic age and cellular senescence: a bibliometric and visual analysis

M kahaer, D Aikeremu, H Wang, K Xu, ZG Sun - bioRxiv, 2024 - biorxiv.org
The aim of this study is to summarize and visualize the current state of research on the
relationship between epigenetic age and cellular senescence over the past two decades …