Natural dietary ROS scavenger-based nanomaterials for ROS-related chronic disease prevention and treatment

J Xie, R Dong, T Zhang, F Guo, H Li, X Chen… - Chemical Engineering …, 2024 - Elsevier
Growing evidence demonstrates that reactive oxygen species (ROS) is closely related to
many chronic disease progressions, such as atherosclerosis and rheumatoid arthritis …

Ursolic acid alleviates chronic prostatitis via regulating NLRP3 inflammasome‐mediated Caspase‐1/GSDMD pyroptosis pathway

S Liu, B Guo, Q Gao, Y Deng, B Yan… - Phytotherapy …, 2024 - Wiley Online Library
Ursolic acid (UA) is a naturally occurring pentacyclic triterpenoid widely found in fruits and
vegetables. It has been reported that UA has anti‐inflammatory effects. However, its efficacy …

Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges

DAE Pitaloka, Y Syaputri, P Nurlilasari… - Drug Design …, 2024 - Taylor & Francis
Tuberculosis (TB) stands as the second most prevalent cause of global human mortality from
infectious diseases. In 2022, the World Health Organization documented an estimated …

Unveiling the potential of ursolic acid modified hyaluronate nanoparticles for combination drug therapy in triple negative breast cancer

R Sharma, V Yadav, S Jha, S Dighe, S Jain - Carbohydrate Polymers, 2024 - Elsevier
Triple negative breast cancer (TNBC) represents the most aggressive and heterogenous
disease, and combination therapy holds promising potential. Here, an enzyme-responsive …

Ursolic acid molecules dock MAPK1 to modulate gut microbiota diversity to reduce neuropathic pain

ZJ Rong, M Chen, HH Cai, GH Liu, JB Chen, H Wang… - …, 2024 - Elsevier
To investigate the efficacy of Ursolic acid in alleviating neuropathic pain in rats with spinal
nerve ligation (SNL), the SNL rat model was surgically induced. Different concentrations of …

[HTML][HTML] Aptamer-functionalized nanomaterials (AFNs) for therapeutic management of hepatocellular carcinoma

X Yin, J Rong, M Shao, S Zhang, L Yin, Z He… - Journal of …, 2024 - Springer
Hepatocellular carcinoma (HCC) represents one of the deadliest cancers globally, making
the search for more effective diagnostic and therapeutic approaches particularly crucial …

[HTML][HTML] Natural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment

S Kowalski, J Karska, M Tota, K Skinderowicz… - Molecules, 2024 - mdpi.com
The elevated occurrence of non-melanoma skin cancer (NMSC) and the adverse effects
associated with available treatments adversely impact the quality of life in multiple …

Ursolic acid inhibits the synaptic release of glutamate and prevents glutamate excitotoxicity in rats

TK Lin, KC Yeh, MS Pai, PW Hsieh, SJ Wang - European Journal of …, 2024 - Elsevier
The present study evaluated the effect of ursolic acid, a natural pentacyclic triterpenoid, on
glutamate release in rat cortical nerve terminals (synaptosomes) and its neuroprotection in a …

[HTML][HTML] UPLC-ESI-MS/MS-Based Analysis of Various Edible Rosa Fruits Concerning Secondary Metabolites and Evaluation of Their Antioxidant Activities

M Ni, J Chen, M Fu, H Li, S Bu, X Hao, W Gu - Foods, 2024 - mdpi.com
The genus Rosa is globally popular with well-established applications since it has a high
edible and medicinal value. However, relatively limited research has been conducted on the …

Design, synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells

W Mei, L Xie, X Zhang, C Shi, F Wang, Q Fu… - Chinese Chemical …, 2024 - Elsevier
Ursolic acid (UA) is a naturally occurring ursane triterpenoid, which exhibits a wide range of
unique biological activities. To clarify its mechanism of action (MOA), a series of fluorescent …