Neurodegenerative diseases are increasing in prevalence and place a significant burden on
society. The causes are multifactorial and complex, and increasing evidence suggests a …

Kinesin-1, composed of kinesin heavy chain and kinesin light chain, is a founding member
of kinesin superfamily and transports various neuronal cargos. Kinesin-1 is one of the most …

Amyotrophic lateral sclerosis (ALS) is a complex, fatal neurodegenerative disease. Disease
pathophysiology is incompletely understood but evidence suggests gut dysbiosis occurs in …

Previous studies have observed a significant comorbidity between Alzheimer's disease (AD)
and some other neuropsychiatric disorders. However, the mechanistic connections between …

Despite substantial progress, causal variants are identified only for a minority of familial
Parkinson's disease (PD) cases, leaving high-risk pathogenic variants unidentified,. To …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which currently
lacks effective treatments. Mutations in the RNA-binding protein FUS are a common cause of …

Background Previous observational studies focused on the association of coffee
consumption and neurological disease. However, it is not known whether these associations …

Amyotrophic lateral sclerosis (ALS) is a mysterious lethal multisystem neurodegenerative
disease that gradually leads to the progressive loss of motor neurons. A recent non-contact …

Brain imaging-derived phenotypes have been suggested to be associated with amyotrophic
lateral sclerosis in observational studies, but whether these associations are causal remains …

Genetic abnormalities play a crucial role in the development of neurodegenerative disorders
(NDDs). Genetic exploration has indeed contributed to unraveling the molecular …