The NLRP3 inflammasome is a multiprotein complex that upon activation by the innate
immune system drives a broad inflammatory response. The primary initial mediators of this …

Pyroptosis, an inflammatory programmed cell death process, has recently garnered
significant attention due to its pivotal role in various neurological diseases. This review …

Inflammation is implicated as a cause in many diseases. Most of the anti-inflammatory
agents in use are synthetic and there is an unmet need for natural substance-derived anti …

ATP and ONOO-play unique roles in various biological events and exhibit notable
interactions. To date, there is no available chemical tool for investigating the correlation …

Resident macrophages are tissue-specific innate immune cells acting as sentinels,
constantly patrolling their assigned tissue to maintain homeostasis, and quickly responding …

Serum ferritin concentrations increase during hepatic inflammation and correlate with the
severity of chronic liver disease. Here, we report a molecular mechanism whereby the heavy …

Viruses have a wide repertoire of molecular strategies that focus on their replication or the
facilitation of different stages of the viral cycle. One of these strategies is mediated by the …

Oxidative stress is characterized by an increase in reactive oxygen species or a decrease in
antioxidants in the body. This imbalance leads to detrimental effects, including inflammation …

Idiopathic pulmonary fibrosis (IPF) is a highly debilitating and fatal chronic lung disease that
is difficult to cure clinically. IPF is characterized by a gradual decline in lung function, which …

Hypoxia/reoxygenation caused by chronic intermittent hypoxia (CIH) plays an important role
in cognitive deficits in patients with obstructive sleep apnea. However, the precise …