Improving polygenic prediction in ancestrally diverse populations
Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As
existing genome-wide association studies (GWAS) have been conducted predominantly in …
existing genome-wide association studies (GWAS) have been conducted predominantly in …
[HTML][HTML] Diversity matters: opportunities in the study of the genetics of psychotic disorders in low-and middle-income countries in Latin America
Lack of diversity regarding genetic and environmental backgrounds weakens the
generalization and clinical applicability of research findings on psychotic disorders. Notably …
generalization and clinical applicability of research findings on psychotic disorders. Notably …
Posttraumatic stress disorder: from gene discovery to disease biology
R Polimanti, FR Wendt - Psychological medicine, 2021 - cambridge.org
Posttraumatic stress disorder (PTSD) is a complex mental disorder afflicting approximately
7% of the population. The diverse number of traumatic events and the wide array of …
7% of the population. The diverse number of traumatic events and the wide array of …
[HTML][HTML] Continuity of genetic risk for aggressive behavior across the life-course
CM Van der Laan, JJ Morosoli-García… - Behavior genetics, 2021 - Springer
We test whether genetic influences that explain individual differences in aggression in early
life also explain individual differences across the life-course. In two cohorts from The …
life also explain individual differences across the life-course. In two cohorts from The …
[HTML][HTML] Biobank-scale methods and projections for sparse polygenic prediction from machine learning
In this paper we characterize the performance of linear models trained via widely-used
sparse machine learning algorithms. We build polygenic scores and examine performance …
sparse machine learning algorithms. We build polygenic scores and examine performance …
Incorporating European GWAS findings improve polygenic risk prediction accuracy of breast cancer among East Asians
Previous genome‐wide association studies (GWASs) have been largely focused on
European (EUR) populations. However, polygenic risk scores (PRSs) derived from EUR …
European (EUR) populations. However, polygenic risk scores (PRSs) derived from EUR …
Integrative Statistical Approaches to Gain Biological Insights from Genome-Wide Association Studies
Y Ji - 2021 - search.proquest.com
Most common human traits such as diabetes, height, Alzheimer's disease, schizophrenia are
complex. These traits are called complex because they are not caused by the dysfunction of …
complex. These traits are called complex because they are not caused by the dysfunction of …
Genome Wide Association Study in the New Haven Lexinome Project Identifies GARRE1 as a Novel Gene for Reading Performance
AK Adams, EL Guertin, DT Truong, EG Atkinson… - bioRxiv, 2021 - biorxiv.org
Despite high prevalence and high heritability, few candidate genes have been identified for
reading disability. To identify novel genetic variants we performed a genome-wide …
reading disability. To identify novel genetic variants we performed a genome-wide …