Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

J Zhang, T Xiao, Y Cai, CL Lavine, H Peng, H Zhu… - Science, 2021 - science.org
The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
outcompeted previously prevalent variants and become a dominant strain worldwide. We …

Spatiotemporal pattern of COVID-19 spread in Brazil

MC Castro, S Kim, L Barberia, AF Ribeiro, S Gurzenda… - Science, 2021 - science.org
Brazil has been severely hit by COVID-19, with rapid spatial spread of both cases and
deaths. We used daily data on reported cases and deaths to understand, measure, and …

Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells

J Mateus, JM Dan, Z Zhang, C Rydyznski Moderbacher… - Science, 2021 - science.org
INTRODUCTION Understanding human immune responses to severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) RNA vaccines is of interest for a panoply of reasons …

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

MML Poon, K Rybkina, Y Kato, M Kubota… - Science …, 2021 - science.org
Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized
in blood; however, most functions of protective immunity must be accomplished in tissues …

CRISPR techniques and potential for the detection and discrimination of SARS-CoV-2 variants of concern

H Xiao, J Hu, C Huang, W Feng, Y Liu… - TrAC Trends in …, 2023 - Elsevier
The continuing evolution of the SARS-CoV-2 virus has led to the emergence of many
variants, including variants of concern (VOCs). CRISPR-Cas systems have been used to …

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

H Tegally, JE San, M Cotten, M Moir, B Tegomoh… - Science, 2022 - science.org
Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing
in Africa over the past year has led to a major increase in the number of sequences that …

Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B. 1.1. 7 emergence

MUG Kraemer, V Hill, C Ruis, S Dellicour, S Bajaj… - Science, 2021 - science.org
Understanding the causes and consequences of the emergence of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants of concern is crucial to pandemic control yet …

Predicting the mutational drivers of future SARS-CoV-2 variants of concern

MC Maher, I Bartha, S Weaver, J Di Iulio… - Science translational …, 2022 - science.org
SARS-CoV-2 evolution threatens vaccine-and natural infection–derived immunity and the
efficacy of therapeutic antibodies. To improve public health preparedness, we sought to …

Estimating epidemiologic dynamics from cross-sectional viral load distributions

JA Hay, L Kennedy-Shaffer, S Kanjilal, NJ Lennon… - Science, 2021 - science.org
Estimating an epidemic's trajectory is crucial for developing public health responses to
infectious diseases, but case data used for such estimation are confounded by variable …

Global disparities in SARS-CoV-2 genomic surveillance

AF Brito, E Semenova, G Dudas, GW Hassler… - Nature …, 2022 - nature.com
Genomic sequencing is essential to track the evolution and spread of SARS-CoV-2, optimize
molecular tests, treatments, vaccines, and guide public health responses. To investigate the …