Von Willebrand factor (VWF) is a plasma glycoprotein best known for its crucial hemostatic
role in serving as a molecular bridge linking platelets to subendothelial components …

Beyond its role in hemostasis, von Willebrand factor (VWF) is an emerging mediator of
vascular inflammation. Recent studies highlight the involvement of VWF and its regulator …

Background Severe coronavirus disease 2019 (COVID‐19) is characterized by an increased
risk of thromboembolic events, with evidence of microthrombosis in the lungs of deceased …

Endothelial cell (EC) activation plays a key role in the pathogenesis of pulmonary
microvascular occlusion, which is a hallmark of severe coronavirus disease 2019 (COVID …

Cirrhosis of the liver is frequently accompanied by complex alterations in the hemostatic
system, resulting in a bleeding tendency. Although many hemostatic changes in liver …

Endothelial dysfunction contributes to the pathogenesis of a variety of potentially serious
infectious diseases and syndromes, including sepsis and septic shock, hemolytic-uremic …

Abstract Weibel-Palade bodies (WPBs) are elongated secretory organelles specific to
endothelial cells that contain von Willebrand factor (VWF) and a variety of other proteins that …

Summary von Willebrand factor (VWF), a glycoprotein involved in arterial thrombus
formation, is released into the circulation by secretion from endothelial cells. Plasma VWF …

Agonist-induced release of endothelial cell specific storage granules, designated Weibel-
Palade bodies (WPBs), provides the endothelium with the ability to rapidly respond to …

Conclusions The endothelium is a key organ involved in the pathogenesis of sepsis.
Dysfunction of or injury to the endothelium may be involved in the pathogenesis of multiple …