Ubiquitylation, a highly regulated post-translational modification, controls many cellular
pathways that are critical to cell homeostasis. Ubiquitin ligases recruit substrates and …

Simple Summary Tumors are ecosystems composed of cancer cells and non-tumor stroma
together in a hypoxic environment often described as wounds that do not heal. Accumulating …

Pancreatic cancer (PC) is a lethal malignancy. Its prevalence rate remains low but continues
to grow each year. Among all stages of PC, metastatic PC is defined as late‑stage (stage IV) …

Background: Lung cancer is a malignant tumor with metastatic potential. Chemokine ligand
14 (CXCL14) has been reported to be associated with different cancer cell migration and …

While a protein primary structure is determined by genetic code, its specific functional form is
mostly achieved in a dynamic interplay that includes actions of many enzymes involved in …

Objective Nowadays, cancer is still a leading public health problem all over the world.
Several studies have reported the GPX8 could be correlated with the poor prognostic of …

The inactivation of tumor suppressor DOC-2/DAB2 interactive protein (DAB2IP) by
epigenetic and post-transcriptional modification has been reported in multiple human …

FBXO31 is the substrate receptor of one of many CUL1-RING ubiquitin ligase (CRL1)
complexes. Here, we show that low FBXO31 mRNA levels are associated with high pre …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC), the most common form of
pancreatic cancer, remains one of the most lethal diseases. Current evidence, discussed in …

F-box and leucine-rich repeat protein 7 (FBXL7), an F-box protein responsible for substrate
recognition by the SKP1-Cullin-1-F-box (SCF) ubiquitin ligases, plays an emerging role in …