Centralized pain syndromes are associated with changes within the central nervous system
that amplify peripheral input and/or generate the perception of pain in the absence of a …

Mast cells are well known for their involvement in allergic and anaphylactic reactions, during
which immunoglobulin E (IgE) receptor (FcɛRI) aggregation leads to exocytosis of the …

Aims Terms used in the field of chronic pelvic pain (CPP) are poorly defined and often
confusing. An International Continence Society (ICS) Standard for Terminology in chronic …

Mast cells are not only necessary for allergic reactions, but recent findings indicate that they
are also involved in a variety of neuroinflammatory diseases, especially those worsened by …

Chronic urticaria (CU) is a mast cell (MC)‐dependent disease with limited therapeutic
options. Current management strategies are directed at inhibiting IgE‐mediated activation of …

Current evidence from clinical and laboratory studies confirms that mast cells play a central
role in the pathogenesis and pathophysiology of interstitial cystitis (IC). In this article, we …

Mast cells are critical for allergic reactions, but also for innate or acquired immunity and
inflammatory conditions that worsen by stress. Corticotropin-releasing hormone (CRH) …

Cystitis, or inflammation of the bladder, has a direct effect on bladder function. Interstitial
cystitis is a syndrome characterized by urinary bladder pain and irritative symptoms of more …

Endometriosis remains an enigmatic disorder in that the cause, the natural history, and the
precise mechanisms by which it causes pain are not completely understood. The pain …

Abstract Aims of Study The Bladder Pain Syndrome Committee of the International
Consultation on Incontinence was assigned the task by the consultation of reviewing the …