[HTML][HTML] Role of oxidative stress and neuroinflammation in attention-deficit/hyperactivity disorder

JC Corona - Antioxidants, 2020 - mdpi.com
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder of
childhood. Although abnormalities in several brain regions and disturbances of the …

Anxiety in asthma: a systematic review and meta-analysis

G Ye, DS Baldwin, R Hou - Psychological Medicine, 2021 - cambridge.org
BackgroundBackground: Growing evidence from observational studies indicates a high
prevalence of anxiety in asthma. However, prevalence rates of coexisting anxiety symptoms …

Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease

M Sharma, D Leung, M Momenilandi… - Journal of Experimental …, 2023 - rupress.org
STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …

[HTML][HTML] Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank

K Valette, Z Li, V Bon-Baret, A Chignon… - Communications …, 2021 - nature.com
To identify candidate causal genes of asthma, we performed a genome-wide association
study (GWAS) in UK Biobank on a broad asthma definition (n= 56,167 asthma cases and …

Association of asthma and its genetic predisposition with the risk of severe COVID-19

Z Zhu, K Hasegawa, B Ma, M Fujiogi… - Journal of Allergy and …, 2020 - jacionline.org
To the Editor: In individuals with severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection, the severity of illness ranges from asymptomatic to fatal. 1 The Centers for …

An atlas of genetic correlations and genetically informed associations linking psychiatric and immune-related phenotypes

DS Tylee, YK Lee, FR Wendt, GA Pathak… - JAMA …, 2022 - jamanetwork.com
Importance Certain psychiatric and immune-related disorders are reciprocal risk factors.
However, the nature of these associations is unclear. Objective To characterize the …

[HTML][HTML] Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study

Z Zhu, Y Li, RJ Freishtat, JC Celedón… - Nature …, 2023 - nature.com
Bronchiolitis is the most common lower respiratory infection in infants, yet its pathobiology
remains unclear. Here we present blood DNA methylation data from 625 infants hospitalized …

[HTML][HTML] Assessing causal relationships between gut microbiota and asthma: evidence from two sample Mendelian randomization analysis

R Li, Q Guo, J Zhao, W Kang, R Lu, Z Long… - Frontiers in …, 2023 - frontiersin.org
Background Accumulating evidence has suggested that gut microbiota dysbiosis is
commonly observed in asthmatics. However, it remains unclear whether dysbiosis is a …

[PDF][PDF] Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity

K Tsuo, W Zhou, Y Wang, M Kanai, S Namba, R Gupta… - Cell genomics, 2022 - cell.com
Asthma is a complex disease that varies widely in prevalence across populations. The
extent to which genetic variation contributes to these disparities is unclear, as the genetics …

[HTML][HTML] Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and …

C Liu, H Makrinioti, S Saglani, M Bowman… - Frontiers in …, 2022 - frontiersin.org
Asthma is a chronic and heterogeneous respiratory disease with many risk factors that
typically originate during early childhood. A complex interplay between environmental …