[HTML][HTML] Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …
DNA methylation methods: Global DNA methylation and methylomic analyses
S Li, TO Tollefsbol - Methods, 2021 - Elsevier
DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …
significant involvement for numerous biological processes in health and disease. The …
DNA methylation QTL mapping across diverse human tissues provides molecular links between genetic variation and complex traits
M Oliva, K Demanelis, Y Lu, M Chernoff, F Jasmine… - Nature …, 2023 - nature.com
Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …
specific characterization of DNAm is needed to understand its role in gene regulation and its …
[HTML][HTML] Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson's disease
Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected
source for cell-based therapies for Parkinson's disease (PD). The regulatory criteria for the …
source for cell-based therapies for Parkinson's disease (PD). The regulatory criteria for the …
[HTML][HTML] Engineering triangular carbon quantum dots with unprecedented narrow bandwidth emission for multicolored LEDs
F Yuan, T Yuan, L Sui, Z Wang, Z Xi, Y Li, X Li… - Nature …, 2018 - nature.com
Carbon quantum dots (CQDs) have emerged as promising materials for optoelectronic
applications on account of carbon's intrinsic merits of high stability, low cost, and …
applications on account of carbon's intrinsic merits of high stability, low cost, and …
Trophoblast organoids as a model for maternal–fetal interactions during human placentation
The placenta is the extraembryonic organ that supports the fetus during intrauterine life.
Although placental dysfunction results in major disorders of pregnancy with immediate and …
Although placental dysfunction results in major disorders of pregnancy with immediate and …
[HTML][HTML] DNA methylation GrimAge version 2
We previously described a DNA methylation (DNAm) based biomarker of human mortality
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
[HTML][HTML] A comprehensive human gastric cancer organoid biobank captures tumor subtype heterogeneity and enables therapeutic screening
Gastric cancer displays marked molecular heterogeneity with aggressive behavior and
treatment resistance. Therefore, good in vitro models that encompass unique subtypes are …
treatment resistance. Therefore, good in vitro models that encompass unique subtypes are …
ChAMP: updated methylation analysis pipeline for Illumina BeadChips
Abstract Summary The Illumina Infinium HumanMethylationEPIC BeadChip is the new
platform for high-throughput DNA methylation analysis, effectively doubling the coverage …
platform for high-throughput DNA methylation analysis, effectively doubling the coverage …
[HTML][HTML] Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance
F Newell, IP da Silva, PA Johansson, AM Menzies… - Cancer cell, 2022 - cell.com
We concurrently examine the whole genome, transcriptome, methylome, and immune cell
infiltrates in baseline tumors from 77 patients with advanced cutaneous melanoma treated …
infiltrates in baseline tumors from 77 patients with advanced cutaneous melanoma treated …