Background: Despite decades of research, little clarity exists regarding pathogenic
mechanisms related to schizophrenia. Investigations on the disease biology of …

Antipsychotic response in schizophrenia is a complex, multifactorial trait influenced by
pharmacogenetic factors. With genetic studies thus far providing little biological insight or …

Background Antipsychotic drugs improve schizophrenia symptoms and reduce the
frequency of relapse, but treatment response is highly variable. Little is known about the …

Background The Patient Global Impression of Severity (PGI-S) scale is a self-reported,
single-item categorical scale that is increasingly used when assessing chronic cough (CC) …

Genomic research is one of the tools for elucidating the pathogenesis of diseases of global
health relevance and paving the research dimension to clinical and public health translation …

Numerous genetic variants have been shown to be associated with antipsychotic response
and adverse effects of schizophrenia treatment. However, the clinical application of these …

Researchers have long been presented with the challenge imposed by the role of genetic
heterogeneity in drug response. For many years, Pharmacogenomics and …

Genetic polymorphism in olanzapine-metabolizing enzymes, transporters and drug targets is
associated with alterations in safety and efficacy. The aim of this systematic review is to …

Mental illness represents a major health issue both at the individual and at the
socioeconomical level. This is partly due to the current suboptimal treatment options …

Objective Clinical response to the atypical antipsychotic paliperidone is known to vary
among schizophrenic patients. We carried out a genome-wide association study to identify …