It is estimated that nearly a third of people who abuse drugs started with prescription opioid
medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in …

Patients over the age 65 are a quickly expanding segment of the US population and
represent a large percentage of patients requiring inpatient care. Older adults are more …

Opioid harm can vary by opioid type. This observational study examined the effect of opioid
type (oxycodone vs. tapentadol) on rates of persistent postoperative opioid use …

By numerous measures, opioid-related harm in the United States has been increasing over
the past 2 decades. Rates of opioid misuse and overdose have reached new highs in recent …

Background while many drug groups are associated with falls in older people, less is known
about absolute increases in risk and how these risks vary across different groups of drugs or …

Importance Although better pain management has guided policies for opioid use over the
past few decades, evidence is limited regarding how patterns of use are associated with the …

Morphine prescribed for analgesia has caused drug-related deaths at an estimated
incidence of 0.3% to 4%. Morphine has pharmacological properties that make it particularly …

Tramadol and tapentadol, two structurally related synthetic opioid analgesics, are widely
prescribed due to the enhanced therapeutic profiles resulting from the synergistic …

Background: Tapentadol is a novel atypical opioid. Anecdotal evidence suggests that
tapentadol has a lower toxicity than conventional opioids. Objectives: To evaluate all single …

Tramadol is a low-level opioid increasingly recommended to treat moderate-to-severe acute
and chronic pain. Although characterized as having fewer opioid-related adverse events, the …