The efficacy of drug therapy results from the complex interplay of multiple processes that
govern drug disposition and response. Most studies to date have focused on the contribution …

Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in humans, are
canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) …

Class III multidrug resistance (MDR) P-glycoproteins (P-gp), mdr2 in mice and MDR3 in
man, mediate the translocation of phosphatidylcholine across the canalicular membrane of …

Background & Aims: We have specified the features of progressive familial intrahepatic
cholestasis type 3 and investigated in 31 patients whether a defect of the multidrug …

For the primary care provider, cholestatic jaundice in infancy, defined as jaundice caused by
an elevated conjugated bilirubin, is an uncommon but potentially serious problem that …

Intrahepatic cholestasis of pregnancy (ICP) is a liver disease of pregnancy with serious
consequences for the mother and fetus. Two pedigrees have been reported with ICP in the …

Disruption of the murine mdr2 (multidrug‐resistance) gene, which encodes a
phosphatidylcholine flippase, leads to a hepatic disorder because of loss of biliary …

Progressive familial intrahepatic cholestasis (PFIC) is a lethal inherited childhood
cholestasis of hepatocellular origin. Different subtypes of PFIC have been described …

SummaryThe clinical findings in 33 patients with progressive familial intrahepatic
cholestasis (PFIC) are presented. Symptoms developed almost invariably before 6 months …

Progressive familial intrahepatic cholestasis (PFIC) type 1, 2 and 3 are due to mutations in
ATP8B1, ABCB11 and ABCB4, respectively. Each of these genes encodes a …