The sequence of chromosome 21 was a turning point for the understanding of Down syndrome. Comparative genomics is beginning to identify the functional components of the …
High-quality and complete reference genome assemblies are fundamental for the application of genomics to biology, disease, and biodiversity conservation. However, such …
R Challis, E Richards, J Rajan… - G3: Genes …, 2020 - academic.oup.com
Reconstruction of target genomes from sequence data produced by instruments that are agnostic as to the species-of-origin may be confounded by contaminant DNA. Whether …
TM Keane, L Goodstadt, P Danecek, MA White… - Nature, 2011 - nature.com
We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the …
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here …
TD Wu, CK Watanabe - Bioinformatics, 2005 - academic.oup.com
Motivation: We introduce gmap, a standalone program for mapping and aligning cDNA sequences to a genome. The program maps and aligns a single sequence with minimal …
University of Utah Weiss Robert B. 14 Dunn Diane M … - Nature, 2004 - nature.com
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report …
RIKEN Genome Exploration Research Group Phase I … - Nature, 2002 - nature.com
Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA …
S Levy, G Sutton, PC Ng, L Feuk, AL Halpern… - PLoS …, 2007 - journals.plos.org
Presented here is a genome sequence of an individual human. It was produced from∼ 32 million random DNA fragments, sequenced by Sanger dideoxy technology and assembled …