Hypertension-induced cognitive impairment: from pathophysiology to public health
Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …
Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial …
P Toth, S Tarantini, A Csiszar… - American Journal of …, 2017 - journals.physiology.org
Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes
Objectives: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for
Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced …
Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced …
Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures
The aging population worldwide is facing a significant increase in age-related non-
communicable diseases, including cardiovascular and brain pathologies. This …
communicable diseases, including cardiovascular and brain pathologies. This …
Impact of Angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series
Background Angiotensin II may be involved in amyloid metabolism in the brain. Angiotensin
receptor blockers (ARBs) may also prevent cognitive decline. Objective To evaluate the …
receptor blockers (ARBs) may also prevent cognitive decline. Objective To evaluate the …
Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer's disease
A Csiszar, S Tarantini, GA Fülöp, T Kiss… - Geroscience, 2017 - Springer
Hypertension in the elderly substantially increases both the risk of vascular cognitive
impairment (VCI) and Alzheimer's disease (AD); however, the underlying mechanisms are …
impairment (VCI) and Alzheimer's disease (AD); however, the underlying mechanisms are …
Polysaccharide of Schisandra Chinensis Fructus ameliorates cognitive decline in a mouse model of Alzheimer's disease
M Xu, T Yan, K Fan, M Wang, Y Qi, F Xiao, K Bi… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance Polysaccharides is an important ingredient of Schisandra
Chinensis Fructus which often appears in ancient prescriptions for forgetfulness or …
Chinensis Fructus which often appears in ancient prescriptions for forgetfulness or …
Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged …
P Toth, A Csiszar, Z Tucsek… - American Journal …, 2013 - journals.physiology.org
Hypertension in the elderly substantially increases the risk of stroke and vascular cognitive
impairment in part due to an impaired functional adaptation of aged cerebral arteries to high …
impairment in part due to an impaired functional adaptation of aged cerebral arteries to high …
Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer's disease
Clinical studies show that cerebral amyloid angiopathy (CAA) associated with Alzheimer's
disease (AD) and arterial hypertension are independent risk factors for cerebral …
disease (AD) and arterial hypertension are independent risk factors for cerebral …
Association of obesity, diabetes and hypertension with cognitive impairment in older age
I Feinkohl, G Lachmann, WR Brockhaus… - Clinical …, 2018 - Taylor & Francis
Background Age-related cognitive impairment is rising in prevalence but is not yet fully
characterized in terms of its epidemiology. Here, we aimed to elucidate the role of obesity …
characterized in terms of its epidemiology. Here, we aimed to elucidate the role of obesity …