Sepsis and septic shock

M Cecconi, L Evans, M Levy, A Rhodes - The Lancet, 2018 - thelancet.com
Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

The pathophysiology of sepsis and precision-medicine-based immunotherapy

EJ Giamarellos-Bourboulis, AC Aschenbrenner… - Nature …, 2024 - nature.com
Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

L Evans, A Rhodes, W Alhazzani, M Antonelli… - Critical care …, 2021 - journals.lww.com
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Executive summary: surviving sepsis campaign: international guidelines for the management of sepsis and septic shock 2021

L Evans, A Rhodes, W Alhazzani, M Antonelli… - Critical care …, 2021 - journals.lww.com
Surviving Sepsis Campaign: International... : Critical Care Medicine Executive Summary:
Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic …

Time to treatment and mortality during mandated emergency care for sepsis

CW Seymour, F Gesten, HC Prescott… - … England Journal of …, 2017 - Mass Medical Soc
Background In 2013, New York began requiring hospitals to follow protocols for the early
identification and treatment of sepsis. However, there is controversy about whether more …

Sepsis associated acute kidney injury

JT Poston, JL Koyner - Bmj, 2019 - bmj.com
Sepsis is defined as organ dysfunction resulting from the host's deleterious response to
infection. One of the most common organs affected is the kidneys, resulting in sepsis …

Landiolol and organ failure in patients with septic shock: the STRESS-L randomized clinical trial

T Whitehouse, A Hossain, GD Perkins, AC Gordon… - Jama, 2023 - jamanetwork.com
Importance Patients with septic shock undergo adrenergic stress, which affects cardiac,
immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse …

[PDF][PDF] Sepsis and septic shock: Guideline-based management

S Dugar, C Choudhary, A Duggal - Cleve Clin J Med, 2020 - christopherreeve.org
Sepsis is a life-threatening organ dysfunction that results from the body's response to
infection. It requires prompt recognition, appropriate antibiotics, careful hemodynamic …

[HTML][HTML] Fluid response evaluation in sepsis hypotension and shock: a randomized clinical trial

IS Douglas, PM Alapat, KA Corl, MC Exline, LG Forni… - Chest, 2020 - Elsevier
Background Fluid and vasopressor management in septic shock remains controversial. In
this randomized controlled trial, we evaluated the efficacy of dynamic measures (stroke …

Sepsis 2018: definitions and guideline changes

LM Napolitano - Surgical infections, 2018 - liebertpub.com
Background: Sepsis is a global healthcare issue and continues to be the leading cause of
death from infection. Early recognition and diagnosis of sepsis is required to prevent the …