We now need more than ever to make genome analysis more intelligent. We need to read,
analyze, and interpret our genomes not only quickly, but also accurately and efficiently …

It has been over a decade since the first publication of a method dedicated entirely to
mapping long-reads. The distinctive characteristics of long reads resulted in methods …

Motivation Protein-to-genome alignment is critical to annotating genes in non-model
organisms. While there are a few tools for this purpose, all of them were developed over 10 …

Genome sequence analysis has enabled significant advancements in medical and scientific
areas such as personalized medicine, outbreak tracing, and the understanding of evolution …

Read mapping is a fundamental step in many genomics applications. It is used to identify
potential matches and differences between fragments (called reads) of a sequenced …

Modern data-intensive applications demand high computational capabilities with strict
power constraints. Unfortunately, such applications suffer from a significant waste of both …

Read alignment is often the computational bottleneck in analyses. Recently, several
advances have been made on seeding methods for fast sequence comparison. We combine …

Genome analysis fundamentally starts with a process known as read mapping, where
sequenced fragments of an organism's genome are compared against a reference genome …

A critical step of genome sequence analysis is the mapping of sequenced DNA fragments
(ie, reads) collected from an individual to a known linear reference genome sequence (ie …

Effectively monitoring the spread of SARS-CoV-2 mutants is essential to efforts to counter
the ongoing pandemic. Predicting lineage abundance from wastewater, however, is …