Perfect adaptation in biology
MH Khammash - Cell Systems, 2021 - cell.com
A distinctive feature of many biological systems is their ability to adapt to persistent stimuli or
disturbances that would otherwise drive them away from a desirable steady state. The …
disturbances that would otherwise drive them away from a desirable steady state. The …
[HTML][HTML] Context-aware synthetic biology by controller design: Engineering the mammalian cell
The rise of systems biology has ushered a new paradigm: the view of the cell as a system
that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides …
that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides …
A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance
Abstract Proportional-Integral-Derivative (PID) feedback controllers are the most widely used
controllers in industry. Recently, the design of molecular PID-controllers has been identified …
controllers in industry. Recently, the design of molecular PID-controllers has been identified …
Universal structural requirements for maximal robust perfect adaptation in biomolecular networks
A Gupta, M Khammash - Proceedings of the National …, 2022 - National Acad Sciences
Adaptation is a running theme in biology. It allows a living system to survive and thrive in the
face of unpredictable environments by maintaining key physiological variables at their …
face of unpredictable environments by maintaining key physiological variables at their …
Cybergenetics: Theory and applications of genetic control systems
MH Khammash - Proceedings of the IEEE, 2022 - ieeexplore.ieee.org
There is no design template more important than DNA. Within the sequences of this
exquisite substance lie the design plans for each of us and for every living organism …
exquisite substance lie the design plans for each of us and for every living organism …
Rapid prototyping and design of cybergenetic single-cell controllers
The design and implementation of synthetic circuits that operate robustly in the cellular
context is fundamental for the advancement of synthetic biology. However, their practical …
context is fundamental for the advancement of synthetic biology. However, their practical …
Control engineering meets synthetic biology: Foundations and applications
Synthetic Biology enables the construction of new genetic circuits with the final goal of
controlling cellular behaviour. However, the noisy nature of biomolecular interactions …
controlling cellular behaviour. However, the noisy nature of biomolecular interactions …
Squaring a circle: to what extent are traditional circuit analogies impeding synthetic biology?
K Ilia, D Del Vecchio - GEN Biotechnology, 2022 - liebertpub.com
Synthetic biology has been significantly shaped by modular design principles through
analogies to electrical and computer engineering. Although convenient, these parallels often …
analogies to electrical and computer engineering. Although convenient, these parallels often …
GAMES: A dynamic model development workflow for rigorous characterization of synthetic genetic systems
Mathematical modeling is invaluable for advancing understanding and design of synthetic
biological systems. However, the model development process is complicated and often …
biological systems. However, the model development process is complicated and often …
[图书][B] Mathematics as a laboratory tool
J Milton, T Ohira - 2021 - Springer
John Milton Toru Ohira Dynamics, Delays and Noise Second Edition Page 1 John Milton Toru
Ohira Mathematics as a Laboratory Tool Dynamics, Delays and Noise Second Edition Page 2 …
Ohira Mathematics as a Laboratory Tool Dynamics, Delays and Noise Second Edition Page 2 …