Aerobic exercise training and resistance exercise training are both well-known for their
ability to improve human health; especially in individuals with type 2 diabetes. However …

Drug transporter proteins are critical to the distribution of a wide range of endogenous
compounds and xenobiotics such as hormones, bile acids, peptides, lipids, sugars, and …

Glucose transporter GLUT1 is a transmembrane protein responsible for the uptake of
glucose into the cells of many tissues through facilitative diffusion. Plasma membrane (PM) …

Cancer cells can inhibit effector T cells (Teff) through both immunomodulatory receptors and
the impact of cancer metabolism on the tumor microenvironment. Indeed, Teff require high …

Sleep and wake have global effects on brain physiology, from molecular changes,,–and
neuronal activities to synaptic plasticity,,,–. Sleep–wake homeostasis is maintained by the …

The facilitative GLUT1 and GLUT3 hexose transporters are expressed abundantly in
macrophages, but whether they have distinct functions remains unclear. We confirmed that …

Insulin, downstream of Akt activation, promotes glucose uptake into fat and muscle cells to
lower postprandial blood glucose, an enforced change in cellular metabolism to maintain …

Proliferating cells, compared with quiescent cells, are more dependent on glucose for their
growth. Although glucose transport in keratinocytes is mediated largely by the Glut1 …

Oncogenic epidermal growth factor receptor (EGFR) signaling plays an important role in
regulating global metabolic pathways, including aerobic glycolysis, the pentose phosphate …

Astrocytes represent central regulators of brain glucose metabolism and neuronal function.
They have recently been shown to adapt their function in response to alterations in …