Neuropsychiatric disorders (ie, mood disorders and schizophrenia) and inflammation are
closely intertwined, and possibly powering each other in a bidirectional loop. Depression …

The microbiota-gut-brain axis is a bidirectional signaling mechanism between the
gastrointestinal tract and the central nervous system. The complexity of the intestinal …

Mendelian randomization studies are often performed in an instrumental variables
framework, using germline genetic variants as instruments for modifiable disease risk factors …

The literature on non-genetic peripheral biomarkers for major mental disorders is broad, with
conflicting results. An umbrella review of meta-analyses of non-genetic peripheral …

Importance Positive associations between inflammatory biomarkers and risk of psychiatric
disorders, including schizophrenia, have been reported in observational studies. However …

Objective This study aimed to systematically appraise the meta‐analyses of observational
studies on risk factors and peripheral biomarkers for schizophrenia spectrum disorders …

The availability of genome-wide genetic data on hundreds of thousands of people has led to
an equally rapid growth in methodologies available to analyse these data. While the …

Background: Schizophrenia is a complex illness in which genetic, environmental, and
epigenetic components have been implicated. However, recently, psychiatric disorders …

Psychiatric diseases exact a heavy socioeconomic toll, and it is particularly difficult to identify
their risk factors and causative mechanisms due to their multifactorial nature, the limited …

Neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, obsessive-
compulsive disorder, and neurodevelopmental disorders such as autism spectrum disorder …