G Conway, D Dewailly… - European journal of …, 2014 - academic.oup.com
Polycystic ovary syndrome (PCOS) is the most common ovarian disorder associated with androgen excess in women, which justifies the growing interest of endocrinologists. Great …
JA Santos-Marcos, M Mora-Ortiz… - Biology of sex …, 2023 - Springer
Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D), are now a widespread pandemic in the developed world. These pathologies show sex …
Objective Health and lifestyle factors are associated with variations in serum testosterone levels in ageing men. However, it remains unclear how age-related changes in testosterone …
S Basaria, SM Harman, TG Travison, H Hodis… - Jama, 2015 - jamanetwork.com
Importance Testosterone use in older men is increasing, but its long-term effects on progression of atherosclerosis are unknown. Objective To determine the effect of …
P JafariNasabian, JE Inglis, W Reilly… - Journal of …, 2017 - joe.bioscientifica.com
A wealth of observational studies show that low testosterone is associated with insulin resistance and with an increased risk of diabetes and the metabolic syndrome. Experimental …
CJ Fernandez, EC Chacko… - European …, 2019 - ncbi.nlm.nih.gov
The single most significant risk factor for testosterone deficiency in men is obesity. The pathophysiological mechanisms involved in male obesity-related secondary hypogonadism …
IR Wallace, MC McKinley, PM Bell… - Clinical …, 2013 - Wiley Online Library
Sex hormone binding globulin (SHBG) is a glycoprotein composed of two 373‐amino‐acid subunits. The SHBG gene and a promotor region have been identified. The SHBG receptor …
Background Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the …
JM Kaufman, B Lapauw, A Mahmoud… - Endocrine …, 2019 - academic.oup.com
This narrative review presents an overview of current knowledge on fertility and reproductive hormone changes in aging men, the factors driving and modulating these changes, their …