Dissection of the genetic basis of Aicardi–Goutières syndrome has highlighted a
fundamental link between nucleic acid metabolism, innate immune sensors and type I …

Recognition of DNA and RNA by endosomal and cytosolic sensors constitutes a central
element in the detection of microbial invaders by the innate immune system. However, the …

Dysfunction in Ataxia-telangiectasia mutated (ATM), a central component of the DNA repair
machinery, results in Ataxia Telangiectasia (AT), a cancer-prone disease with a variety of …

Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

Investigations of patients with systemic lupus erythematosus have applied insights from
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …

Organisms throughout biology need to maintain the integrity of their genome. From bacteria
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …

Highlights•Individual ISGs have measurable phenotypes in vivo.•ISGs control viral
pathogenesis through a variety of mechanisms.•ISG effects in vivo are often virus-specific …

To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell,
co-opting mechanisms of cellular physiology while defeating restriction factors that are …

Aicardi–Goutières syndrome (AGS) provides a monogenic model of nucleic acid‐mediated
inflammation relevant to the pathogenesis of systemic autoimmunity. Mutations that impair …

Type I interferon is a potent substance. As such, the induction, transmission, and resolution
of the type I interferon–mediated immune response are tightly regulated. As defined, the type …