Transient receptor potential canonical (TRPC) channels: then and now
Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
Phosphoinositide regulation of TRP channels
T Rohacs - Mammalian Transient Receptor Potential (TRP) Cation …, 2014 - Springer
Abstract Transient Receptor Potential (TRP) channels are activated by stimuli as diverse as
heat, cold, noxious chemicals, mechanical forces, hormones, neurotransmitters, spices, and …
heat, cold, noxious chemicals, mechanical forces, hormones, neurotransmitters, spices, and …
Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol
U Storch, AL Forst, F Pardatscher… - Proceedings of the …, 2017 - National Acad Sciences
The activation mechanism of the classical transient receptor potential channels TRPC4 and-
5 via the Gq/11 protein-phospholipase C (PLC) signaling pathway has remained elusive so …
5 via the Gq/11 protein-phospholipase C (PLC) signaling pathway has remained elusive so …
Phosphoinositide regulation of TRPV1 revisited
T Rohacs - Pflügers Archiv-European Journal of Physiology, 2015 - Springer
The heat-and capsaicin-sensitive transient receptor potential vanilloid 1 ion channel
(TRPV1) is regulated by plasma membrane phosphoinositides. The effects of these lipids on …
(TRPV1) is regulated by plasma membrane phosphoinositides. The effects of these lipids on …
Lipids at membrane contact sites: cell signaling and ion transport
Communication between organelles is essential to coordinate cellular functions and the
cell's response to physiological and pathological stimuli. Organellar communication occurs …
cell's response to physiological and pathological stimuli. Organellar communication occurs …
Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels
Transient Receptor Potential Canonical (TRPC) proteins form nonselective cation channels
commonly known to be activated downstream from receptors that signal through …
commonly known to be activated downstream from receptors that signal through …
Dual action of the Gαq-PLCβ-PI(4,5)P2 pathway on TRPC1/4 and TRPC1/5 heterotetramers
The transient receptor potential canonical (TRPC) 1 channel is widely distributed in
mammalian cells and is involved in many physiological processes. TRPC1 is primarily …
mammalian cells and is involved in many physiological processes. TRPC1 is primarily …
STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes
Ca 2+ influx by plasma membrane Ca 2+ channels is the crucial component of the receptor-
evoked Ca 2+ signal. The two main Ca 2+ influx channels of non-excitable cells are the Orai …
evoked Ca 2+ signal. The two main Ca 2+ influx channels of non-excitable cells are the Orai …
Endoplasmic Reticulum‐Plasma Membrane Contact Sites as an Organizing Principle for Compartmentalized Calcium and cAMP Signaling
T Crul, J Maléth - International Journal of Molecular Sciences, 2021 - mdpi.com
In eukaryotic cells, ultimate specificity in activation and action—for example, by means of
second messengers—of the myriad of signaling cascades is primordial. In fact, versatile and …
second messengers—of the myriad of signaling cascades is primordial. In fact, versatile and …
Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels
Transient receptor potential canonical (TRPC) 4 and TRPC5 channels are modulated by the
Gαq-PLC pathway. Since phosphatidylinositol 4, 5-bisphosphate (PI (4, 5) P2) maintains …
Gαq-PLC pathway. Since phosphatidylinositol 4, 5-bisphosphate (PI (4, 5) P2) maintains …