Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …

Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Current imaging approaches limit the ability to perform multi-scale characterization of three-
dimensional (3D) organotypic cultures (organoids) in large numbers. Here, we present an …

Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …

Organoids show great potential in clinical translational research owing to their intriguing
properties to represent a near physiological model for native tissues. However, the …

The kidney is frequently involved in adverse effects caused by exposure to foreign
compounds, including drugs. An early prediction of those effects is crucial for allowing novel …

Organoids are three-dimensional cell cultures mostly from tissue-resident or embryonic stem
cells (one or multiple) on hydrogels along with defined growth factors. Currently, matrigel is …

While pluripotent stem cell-derived kidney organoids are now being used to model renal
disease, the proximal nephron remains immature with limited evidence for key functional …

There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …

Advanced in vitro kidney models are of great importance to the study of renal physiology and
disease. Kidney tubuloids can be established from primary cells derived from adult kidney …