Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor
vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical …

The treatment of osteochondral defects (OCD) remains challenging. Among currently
available surgical treatments for OCDs, scaffold-based treatments are promising to …

Intrinsically present bioactive cues allow naturally derived materials to mimic important
characteristics of cartilage while also facilitating cellular recruitment, infiltration, and …

Nanocellulose deserves special attention among the large group of biocompatible
biomaterials. It exhibits good mechanical properties, which qualifies it for potential use as a …

Hyaline cartilage regeneration remains clinically challenging. In this study, microbial
transglutaminase was used to cross-link gelatin. The articular cartilage extracellular matrix …

Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. In ACI
a biopsy is taken from a non-load bearing area of the knee and expanded in-vitro. The …

A significant expansion of autologous chondrocytes in vitro is required for cell-based
cartilage repair. However, the in vitro expansion of chondrocytes under standard culture …

Spheroids derived from human mesenchymal stem cells (hMSCs) are of limited use for
cartilage regeneration, as the viability of the cells progressively decreases during the period …

Background The self-assembling process of cartilage tissue engineering is a promising
technique to heal cartilage defects, preventing osteoarthritic changes. Given that …

The preservation of the chondrogenic phenotype and hypoxia-related physiological
microenvironment are major challenges in the 2D culture of primary human chondrocytes …